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KMID : 0370220040480010030
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Yakhak Hoeji
2004 Volume.48 No. 1 p.30 ~ p.33
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Effect of Hexane Extract of Acori graminei Rhizoma on Chloramphenicol Acetyltransferase of Staphylococcus aureus SA2
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문경호/Moon KH
권주열/박민수/김혜경/이정규/Kwon JY/Park MS/Kim HK/Lee CK
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Abstract
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One subfraction from the hexane fraction of Acori graminei Rhizoma, the E4 fraction which is mainly consisted of acorenone, showed a potential inhibitory activity again st chloramphenicol acetyltransferase (CAT) of S. aureus SA2 that is a multidrug-resistant strain to 10 usual antibiotics. The combination therapy of this fraction with chloramphenicol resulted in reduction of the minimal inhibitory concentration from 128 μg/ml to 8 μg/ml. The E4 fraction also revealed to prevent the induction of CAT from this strain.
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